New Game in Town for Latent TB

A 9-month course of daily isoniazid has been the go-to drug for latent tuberculosisbut quite often it causes liver damage, a deterrent for many patients who aren’t sick, and will probably never be sick from the condition, writes Helen Branswell.

Twin studies on children and adults, published Wednesday in the New England Journal of Medicine, suggest what researchers have long believed: Another drug, rifampin, is just as effective, and its 4 month course stands a better chance of completion. A larger study would be needed to uncover whether it is actually more effective than isoniazid. For now, the researchers can rest assured that it’s not inferior.


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