Fingerprints in the Genome

Despite decades of investigation, no one really knows why hotspots of certain cancers exist. For example, a worldwide average of 5.9 people per 100,000 develop esophageal cancer each year, but in Malawi that number is 24 in 100,000.
 
To solve these mysteries, the Mutographs of Cancer project is analyzing tumor DNA to build a database of “fingerprints” left behind by mutational processes, like those caused by UV light.
 
The project’s findings could save thousands of lives, but there’s a long road ahead, involving “a combination of large-scale epidemiology and large-scale genomics that haven’t been married together in this way before,” says team leader Mike Stratton.
 
Mosaic

Comments +

0 comments

Post a Comment

Restricted HTML

  • Lines and paragraphs break automatically.
  • Web page addresses and email addresses turn into links automatically.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Back to top