New Vax Does Double Duty

A promising new vaccine is poised to take on both Lassa fever and rabies, according to new research published in Nature Communications.

Both diseases take a toll in Africa, where access to rabies vaccines and post-exposure shots can be scarce; there is currently no approved vaccine Lassa virus, which is endemic to West Africa.

In preclinical trials using mice and guinea pigs, researchers inserted Lassa virus genetic material into a weakened rabies vector so the vaccine, LASSARAB, expressed surface proteins from both viruses, sparking an immune response against them. The investigational vaccine shielded guinea pigs from Lassa fever 58 days after vaccination.

NIH (News Release)

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