CRISPR’s New Breakthrough—Disarming Parasites

George Washington School of Medicine researchers have successfully used CRISPR/Cas9 in animal models to reduce harm caused by the parasites behind schistosomiasis and liver fluke infections.

The worms, which enter the body by burrowing into the skin (schistosomiasis) or via undercooked fish (liver fluke), release proteins causing extensive liver, kidney and other organ damage. Using CRISPR/Cas9 to locate and “knock out” these proteins halts the injury the infections cause—another example of the technology’s potential.

“This revolutionary new biomedical procedure can be adapted to study helminth parasites,” says lead author Paul Brindley. “(Those) are a major public health problem in tropical climates.”

ScienceDaily


 

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