Testing a Perfect Score

Scientists are preparing to kick off a clinical trial in Equatorial Guinea for a malaria vaccine that can provide 100% protection against the disease.

The goal: To show regulators that the product is safe and effective. If all goes well, an even bigger trial will follow.

Unlike most candidate vaccines, PfSPZ has whole parasites as its main ingredient (as opposed to genetically engineered parasite proteins) and triggers an immune response against Plasmodium falciparum.

“This trial will be answering several questions for the first time, including whether a vaccine can completely eliminate malaria from this island environment,” says Seattle Children’s Hospital immunologist Stefan Kappe.


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