CRISPR Twins Given Rare and Risky Genetic Variant

The case against a Chinese scientist’s “CRISPR twins” experiment has been laid out in Nature Medicine.

He Jiankui attempted to engineer human embryos with a rare genetic variant known for protecting against HIV infection—but which also comes with a 21% higher mortality rate compared to the more common variant, University of California, Berkeley researchers wrote.

A newly released email from January suggests that He, too, was concerned about the risks: “I pushed too quickly into a first-of-kind clinical study without the necessary open dialog with regulators, the scientific community, and the public,” he wrote to bioethicist William Hurblut.



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