‘Decay-Stimulation-Decay’

Ebola survivors’ antibody levels against the disease wax and wane over time, according to new research that has important implications for tracking variable immunity to other viruses, Nature reports.
 
In the first study of its kind, researchers tracked the ubiquitous ‘IgG’ antibodies in 115 Ebola survivors for up to 500 days post-infection.
 
A substantial proportion of survivors experienced antibody resurgence ~200–300 days after recovery—but then antibody levels then decayed again.
 
An important implication is that Ebola vaccine boosters may be needed to maintain survivors’ defenses. However, some vaccines trigger fairly stable immune responses against Ebola, suggesting this ebb and flow feature may be unique to naturally acquired immunity.  

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