Vaccine developers are already adapting first-generation COVID vaccines to get ahead of new variants could possibly evade them.
While variants have been shown to reduce the effects of antibodies, it’s unclear how much that impacts the vaccine’s overall power.
Data Question: Updated vaccines seem inevitable—but an open question is how much data will be required for these updated vaccines to prove their worth. Seasonal flu vaccines don’t require fresh clinical trials—but regulators have decades of experience and data to rely on.
The decision may come down to whether scientists can measure immune responses without waiting for participants to become infected in order to know whether the shots are working.