What Antibodies Tell Us—And What They Don’t

Antibody-mediated herd immunity has not been achieved in most regions, according to a Lancet Global Health meta-analysis of 400 published and preprint serological studies from across the globe.

Key Finding: Less than 10% of the general population has been exposed to SARS-CoV-2, according to the analysis. 

It also found that risk of infection was significantly higher among Blacks and Asians compared to whites, and also higher among working-age adults than younger of older groups.  
 
These are useful insights, but should be taken with a grain of salt, notes an accompanying commentary.
 
The waning of antibodies—some faster than others—suggest seroprevalence data may underestimate the true number of infections. Plus, antibody tests don’t account for other immune system tools like T-cells.

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