Next-Gen COVID Vaccines

Our immune response to SARS-CoV-2 centers on the virus’s spike protein. All 3 COVID vaccines authorized in the US are based on a modified version of spike called 2P. A new, more resilient version called HexaPro may be even better.
The new design, co-developed by the University of Texas at Austin’s Jason McLellan and colleagues, features not 2 but 6 modifications that lock spike into its pre-weaponized form—fueling infection-fighting antibodies that can neutralize the virus before it invades cells, UT News reports.
And, scientists at the Icahn School of Medicine at Mount Sinai have successfully cultured harmless HexaPro-covered viruses in chicken eggs, The New York Times reports. The resulting vaccine, NDV-HXP-S, is now entering clinical trials in Vietnam, Thailand, Brazil, and Mexico.
If safe and effective, NDV-HXP-S could be cheaply manufactured using existing factories many countries already use to make flu shots—which could allow many LMICs to make NDV-HXP-S themselves.

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