A Vaccine for Opioid Overdose?

Researchers are conducting the first-ever human trials of a vaccine against opioid overdose.
The trial involves giving participants in active phases of addiction non-lethal doses of opioids, including heroin, after receiving the experimental vaccine.
How does it work? Using the basic principle of vaccines. The shot “triggers the patient's own immune system to develop antibodies against the target”—in this case, oxycodone, says trial co-lead Marco Pravetoni, of the University of Minnesota Medical School. 
What it doesn’t do: Prevent drug cravings—so it would likely be paired up with medications that do.


Pharmacy chains failed to prevent opioid misuse, U.S. jury hears – NPR

McKinsey Never Told the FDA It Was Working for Opioid Makers While Also Working for the Agency – ProPublica

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