US emergency department (ED) visits for suspected opioid overdoses jumped 30% from July 2016-September 2017. The increase spanned men and women across all age groups and regions, according to the CDC’s latest Vital Signs report.

It’s ever-harder to do justice to the gravity of the US opioid crisis, but TIME goes some way in its first-ever issue dedicated to a single topic.Tracking users, first responders, families, funerals and recoveries, James Nachtwey’s haunting photos are nothing short of war…

Canada’s “harm reduction” approach to the opioid crisis is gradually being emulated by US cities including San Francisco, risking a face-off with the Justice Department.British Columbia—the heart of Canada’s opioid crisis—now has 29 sites to safely inject drugs, provided by…

In New Hampshire, a hotbed of America’s opioid crisis, the New York Times shadowed Patrick Griffin and his family's struggle with addiction—marked by countless overdoses, clean periods, jail stints, treatment programs, and constant anxiety.Overdose is the leading killer of…

A line-up of multidisciplinary scientists have 4 years and a $10 million Department of Defense grant to find an oceanic opioid alternative.

The glut of opioids fueling America’s epidemic is scuppering access to the drugs in poor countries suffering from severe pain more than opioid abuse.

Like America, Russia is battling a severe opioid crisis—but it has adopted a starkly different, “tough-love” approach in response.

Mexico’s bungled war on organized crime has killed 150,000—and a legion of community police fighting corrupt officials and cartels alike have found themselves in the crosshairs.

Former President Bill Clinton and researcher G. Caleb Alexander discuss why opioid-related deaths are still increasing and the best solutions.

When it comes to understanding America’s opioid epidemic, overdose numbers don’t tell the full story.